Table 1.
Patient characteristics and treatment details.
| Patient | Tumour type | Age at diagnosis | Initial treatment and carboplatin dosing regimen | Number of courses of carboplatin | TDM approach taken |
|---|---|---|---|---|---|
| 001 | Retinoblastoma (bilateral) | 52 weeks gestational age (born at 28 weeks) | Single agent carboplatin 100 mg/m2/day ×3; target AUC 5.2 mg/ml mina,d | 6 | TDM used to achieve target AUC on course 1. Good response and tolerability so equivalent mg/kg dosing used for courses 2–6 |
| 002 | Retinoblastoma (bilateral) | 3 days (gestational age of 40 weeks) | Single agent carboplatin to target AUC 5.8 mg/ml mina | 6 | TDM used to achieve target AUCs on courses 1/2. Good response after courses 1 and 2 so equivalent mg/m2 dosing used for courses 3–6 |
| 003 | Neuroblastoma (low risk stage 4s) | 2 weeks (gestational age of 37 weeks) | Carboplatin (6.6 mg/kg)/etoposide (5 mg/kg) | 1 | TDM proposed to determine AUC achieved on course 1 |
| 004 | Neuroblastoma (low risk, localised, un-resectable) | 3 days (gestational age of 40 weeks) | Carboplatin (4.4 mg/kg)/etoposide (5 mg/kg) | 2 | TDM used to determine AUCs achieved on courses 1 and 2. Good response and tolerability following mg/kg dosing on both courses |
| 005 | Retinoblastoma (bilateral) | 35 weeks gestational age (born at 32 weeks) | Single agent carboplatin (6.6 mg/kg); target AUC 5.2 mg/ml mina | 5 | TDM used to achieve target AUC on courses 1–3. Good response and tolerability so equivalent mg/kg dosing used for courses 4/5 |
| 006 | Retinoblastoma (bilateral) | 3 weeks (gestational age of 40 weeks) | JOEb ×6 cycles; carboplatin dose 100 mg/m2/day ×3; target AUC 7.7 mg/ml min | 4 | TDM used to achieve target AUC on course 1. Good response and tolerability so equivalent mg/m2 dosing used for courses 2–4 |
| 007 | Retinoblastoma (left) | 1 week (gestational age of 40 weeks) | JOEb ×3 cycles; carboplatin dose 6.6 mg/kg/day ×3; target AUC 7.8 mg/ml minc | 3 | TDM used to achieve target AUCs on courses 1/2. Good response and tolerability so equivalent mg/kg dosing used for course 3 |
| 008 | Retinoblastoma (bilateral) | 36 weeks gestational age (born at 29 weeks) | Single agent carboplatin to target AUC 5.2 mg/ml min a | 3 | TDM used to achieve target AUC on courses 1–3 |
| 009 | Retinoblastoma (right) | 3 weeks (gestational age of 40 weeks) | Single agent carboplatin (6.6 mg/kg) to target AUC 5.8 mg/ml min a | 2 | TDM used to achieve target AUC on courses 1 and 2 |
TDM – therapeutic drug monitoring.
a
Patient also received local laser treatment.
b
JOE – vincristine, etoposide and carboplatin.
c
Patient also received thermotherapy.
d
Patient also received cryotherapy.