Table 3.
Carboplatin clearance values observed on courses 1–3 of treatment.
| Patient | Carboplatin course 1 |
Carboplatin course 2 |
Carboplatin course 3 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BW (kg) | SA (m2) | Daily dose (mg) | Cla (ml/min) | BW (kg) | SA (m2) | Daily Dose (mg) | Cla (ml/min) | BW (kg) | SA (m2) | Daily dose (mg) | Cla (ml/min) | |
| 001 | 4.1 | 0.26 | 26 | 15.5 | ||||||||
| 002 | 3.7 | 0.25 | 24–41 | 18.5 | 4.5 | 40 | 17.6 | |||||
| 003 | 3.5 | 0.24 | 15 | 19.4 | ||||||||
| 004 | 3.6 | 15 | 14.1 | 3.9 | 0.26 | 17 | 14.6 | |||||
| 005 | 1.6 | 4.5–11 | 3.4 | 2.3 | 11–16 | 5.6 | 2.7 | 15–20 | 7.1 | |||
| 006 | 4.0 | 0.26 | 23–25 | 9.6 | ||||||||
| 007 | 3.2 | 20–30 | 12.7 | 3.6 | 30 | 12.0 | ||||||
| 008 | 2.0 | 0.16 | 7–18 | 7.2 | 2.8 | 0.20 | 18 | 9.0 | 3.8 | 0.20 | 25 | 16.5 |
| 009 | 3.2 | 0.21 | 21 | 11.0 | 3.9 | 0.26 | 26–38 | 11.0 | ||||
BW – body weight; SA – surface area; Cl – clearance.
a
Mean clearance values shown where carboplatin pharmacokinetics determined on more than one day of a particular course of treatment.