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Accumulation of histone methylation in HEK293 cells treated with the indicated FQ. A, H3K9me2, H3K27me2, H3K9me3, and H3K27me3 abundance by Western blotting after 4 h of treatment with the indicated FQs (0.5 mm). B, H3K27me2 and H3K9me2 abundance after 2, 4, and 6 h of treatment with CIPRO (0.1 or 1 mm). C, FQ inhibition of jumonji domain histone demethylases in cell culture is rescued by inclusion of the indicated concentrations of ferric citrate (C6H5FeO7). NT, diluent only.
