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FQ inhibition of the TET Fe/O2/2-KG-dependent dioxygenase enzyme is rescued after ferric citrate treatment. HEK293 cells were treated with proposed drugs or co-treated with 300 μm ferric citrate. Data are means ± S.D. reflecting n ≥3 independent experiments. Statistical analysis by paired t test (compared NT control, diluent only) is shown. Statistical significance (**, p ≤ 0.05; ***, p ≤ 0.005) is shown.
