Figure 3.

Example of the integration of mGWAS results in a biomedical context using data from different sources. This figure displays a ‘Cardiovascular disease and hypertension metabolic sub-network’, annotated based on correlations between molecular relationships and expert knowledge on blood pressure regulation, blood coagulation and known molecular risk factors for cardiovascular disease and hypertension. Metabolites (circles) and genes (diamonds) of the fibrinogen cleavage (left) and the kininogen/kinin system (right) and their interconnections were derived from the Shin et al. (see shaded box in Fig. 2) data. Gray nodes and edges display annotations of biochemical function based on expert knowledge (47). Colored nodes and edges correspond to reported associations based on genome-wide studies for blood pressure regulation (orange), blood coagulation (blue) and cholesterol levels (purple). This figure was first published as the Supplementary Material, Fig. S5 by Shin et al., Nature Genetics, 2014 (23).