Fig. 4.

Plasma lipids and metabolic factors. Fasted levels of cholesterol (a), triacylglycerols (b), NEFA (c), leptin (d), resistin (e), interleukin 6 (f), GIP (g), peptide YY (h) and glucagon (i) in 40-week-old mice (n = 8–12). Dark blue, CD-fed Ins1 ^−/−:Ins2 ^+/+ mice; dark purple, HFD-fed Ins1 ^−/−:Ins2 ^+/+ mice; light blue, CD-fed Ins1 ^−/−:Ins2 ^+/− mice; light purple, HFD-fed Ins1 ^−/−:Ins2 ^+/− mice. Data are means ± SEM. *p ≤ 0.05, CD vs HFD; *^+/+ p ≤ 0.05, CD-fed vs HFD-fed Ins1 ^−/−:Ins2 ^+/+ mice; ^†HFD p ≤ 0.05, HFD-fed Ins1 ^−/−:Ins2 ^+/+ vs Ins1 ^−/−:Ins2 ^+/− mice