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. 2015 Jul 23;24(19):5524–5541. doi: 10.1093/hmg/ddv283

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Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 5. — Muscle fiber size upon deletion with Nestin-Cre and ChAT-Cre. The gastrocnemius muscle from (A) control, (B) SMA, (C) Nestin-Cre Smn-deletion mice and (D) Nestin-Cre + ChAT-Cre Smn-deletion mice were measured at P8. Myofiber size in control mice at P8 (mean 387.8 ± 3.3 µm²; median 379.5 µm²) is significantly different from that of Nestin-Cre Smn-deletion mice (mean 277.5 ± 2.3 µm²; median 277.0 µm²), Nestin-Cre + ChAT-Cre Smn-deletion mice (mean 257.4 ± 2.5 µm²; median 247.0 µm², P < 0.001). The Nestin-Cre + ChAT-Cre Smn-deletion mice however have myofiber areas similar to that of SMNΔ7 SMA mice at P8 (Mean 210.6 ± 1.9 µm²; median 205.1 µm²) (51). (E–H) The difference in myofiber area is more dramatic at P21 where (E) control mice (mean 835.9 ± 8.8 µm²; median 757.0 µm²) and (F) ChAT-Cre deletion mice (mean 559.6 ± 6.1 µm², median 530.5 µm²) display larger fibers as compared with (G) Nestin-Cre deletion mice (mean 477.6 ± 4.8 µm², median 447.0 µm²) and (H) Nestin-Cre + ChAT-Cre Smn-deletion mice (mean 302.7 ± 3.2 µm²; median 281.0 µm², P < 0.001). There is no comparison to SMNΔ7 SMA mice at this time point because the SMNΔ7 SMA mice only live for 14 days. For each group, a total of 1500 fibers were measured from 3 mice (approx. 500 fibers per mouse).