Table 3.
Association replication results in two independent cohorts from UK and Finland, replicating several SNPs from both candidate loci (PCDH20 on chromosome 13 and SLC28A3 on chromosome 9) at a nominal significance level (P < 0.05)
| SNP | Trait and model | EA | AA | N | Beta | SE beta | P | Cohort |
|---|---|---|---|---|---|---|---|---|
| rs111887296 | 1 kHz add | T | C | 5892 | −0.0109 | 0.005435 | 0.04495 | B58C |
| rs113274536 | 1 kHz add | T | C | 5892 | −0.0111 | 0.005431 | 0.04072 | B58C |
| rs75281867 | 1 kHz add | C | T | 5892 | −0.0110 | 0.005432 | 0.04215 | B58C |
| rs77604362 | 1 kHz add | T | C | 5892 | −0.0110 | 0.005433 | 0.04239 | B58C |
| rs35664751 | 0.5 kHz add | G | A | 266 | 0.1017 | 0.046187 | 0.02761 | FITSA |
SNP, single nucleotide polymorphism; add, additive; EA, effect allele; AA, alternative allele; N, number of samples; Beta, beta coefficients; SE, standard error; P, P-value.