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HCO3- dependence of TMP-induced ISC increase in Caco-2 cells. Representative ISC recording with arrows indicating TMP (5 mmol/L) added basolaterally, which was abolished by apical application of glybenclamide. Values are mean ± SE; aP < 0.05, bP < 0.01 and cP < 0.001. A: Normal; B: Cl-free; C: K-HS, comparison of TMP-induced total charges transferred in normal and Cl--free K-HS.
