Table 1.
Liver function tests during the 10-day observation period
| Day 2 | Day 5 | Day 10 | ||
| Total Bilirubin (mg/dL) | A | 0.53 ± 0.05 | 0.33 ± 0.05 | 0.35 ± 0.10 |
| B | 0.60 ± 0.10 | 0.46 ± 0.05 | 0.37 ± 0.14 | |
| C | 0.86 ± 0.10 | 0.76 ± 0.10 | 1 | |
| D | 0.86 ± 0.15 | 0.66 ± 0.15 | 0.20 ± 0.10 | |
| SGPT (IU/L) | A | 273 ± 76.2 | 67.5 ± 32.1 | 29.2 ± 11 |
| B | 400.3 ± 155 | 61.6 ± 27.7 | 54.8 ± 25.0 | |
| C | 710 ± 29.3 | 90.3 ± 23.1 | 1 | |
| D | 507.3 ± 91.2 | 66 ± 22.7 | 56.3 ± 14.9 | |
| SGOT (IU/L) | A | 380.6 ± 63.4 | 68.3 ± 24.1 | 84 ± 13.3 |
| B | 779.3 ± 235.2 | 287.6 ± 114 | 76.8 ± 30.9 | |
| C | 1088.3 ± 131.7 | 610.6 ± 148.6 | 1 | |
| D | 836.6 ± 171.2 | 250.6 ± 139.6 | 112 ± 63.2 | |
| Alkaline Phosphatase (IU/L) | A | 469.3 ± 157.5 | 427.6 ± 129.5 | 343.1 ± 180.5 |
| B | 88.6 ± 50 | 58.6 ± 39 | 564.3 ± 142.7 | |
| C | 123.6 ± 50.5 | 116.3 ± 37.4 | 1 | |
| D | 104 ± 31.1 | 129.3 ± 41.7 | 792.3 ± 246.5 | |
All differences between final and baseline values were statistically significant. 1All animals died before d 10. (Normal Values: Total Bilirubin: 0.18 ± 0.07 mg/dL, SGPT: 44.1 ± 24.8 IU/L, SGOT: 53.4 ± 23.6 IU/L, Alk. Phosphatase: 86.8 ± 49.6 IU/L -Baseline Value: Total Bilirubin: 0.6 ± 0.09 mg/dL, SGPT: 616.1 ± 117.5 IU/L, SGOT: 1296.7 ± 381.2 IU/L, Alk. Phosphatase: 91.4 ± 63 IU/L).