Fig. 10.

Fits of 1 and 2 compartment models to stady-state cAMP wash in data. Experimental data (red and blue circles) are as described in Fig. 7. A: simulation results for a 1 compartment model (brown squares) fit to experimental data. It is apparent from these results that a one compartment model does not adequately fit the data. B: steady-state results from a 2 compartment model (green squares) display a clear right shift from the excised patch concentration response (solid lines) and better fit the experimental data.