Fig. 1.

Rab11A and rab11B do not regulate large-conductance Ca²⁺-activated K⁺ channel (BK)α protein trafficking in cerebral artery myocytes. A: representative Western blots illustrating BKα, rab11A, rab11B, and actin total protein in cerebral arteries transfected with scrambled, rab11A short hairpin vector (shV) or rab11B siRNA. B: mean data (n = 6 for each). *P < 0.05 vs. control shV. C: representative Western blots illustrating plasma membrane (M) and intracellular (I) BKα protein obtained from surface biotinylation experiments in cerebral arteries transfected with scrambled, rab11A shV or rab11B siRNA. Lanes are contiguous in each blot. D: mean data (n = 6 for each). *P < 0.05 vs. respective controls.