Fig. 6.

Effects of P2Y₁ antagonist and deletion on outward currents activated by UTP in PDGFRα⁺ cells. A: UTP (10 μM) activated outward currents in PDGFRα⁺ cells from wild-type mice before and after the addition of MRS2500 (1 μM; HP = −40 mV). B: expanded timescales showing responses to ramp potentials during only MRS2500 (a) and with MRS2500 and UTP (b) from the points denoted in A. C: UTP (10 μM) also activated outward currents at −40 mV in PDGFRα⁺ cells from P2ry₁^−/−/eGFP mice. D: current traces at expanded timescales during ramp potentials in control conditions (a) and after the addition of UTP (b) from points denoted in C. Horizontal dotted lines in A–D denote 0 pA. Arrowheads denote the applications of ramp potentials.