Fig. 4.

Na⁺ current in human colonic myocytes is shear sensitive. A: representative traces of human colon myocyte Na⁺ current evoked by steps from −100 mV to −80 through +35 mV in 5-mV intervals, recorded with extracellular solution and perfused at 0 (Control, left) or 10 (Shear stress, right) ml/min. B: average peak current-voltage relationships before (black circles) or during (gray circles) perfusion. Solid lines are Boltzmann fits. C, Time to peak activation. n = 6 cells, *P < 0.05 by 2-tailed Student's t-test.