Fig. 7.

Ranolazine decreases human colon smooth muscle contractility. A: representative muscle bath contractility traces from a human ascending colon muscle strip before and after the addition of 300 μM ranolazine, showing a decrease in resting tone and spontaneous contractions. B–D: mean baseline tension (B), contraction amplitude (C), and contraction frequency (D). E: representative muscle bath contractility traces from a human ascending colon muscle strip before and after the addition of 300 μM ranolazine, showing a decrease in peak response to EFS. F: mean peak response to electrical field stimulation (EFS) of 9–19 strips from 10 preparations. *P < 0.05 by 2-tailed Student's t-test.