Fig. 8.

Pendrin gene ablation increases stress-induced catecholamine release. Blood was sampled for epinephrine and norepinephrine, the norepinephrine metabolite dihydroxyphenylglycerol (DHPG), and for dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), before and 5 and 20 min after initiation of immobilization stress. Values were compared between pendrin-null and wild-type mice at each of these time points using an unpaired, 2-tailed, Student's t-test. After 20 min of immobilization stress, epinephrine and norepinephrine levels were significantly higher in pendrin-null than in wild-type mice. Wild-type, n = 6; pendrin-null, n = 5. *P < 0.05.