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Pendrin gene ablation increases stress-induced release of corticosterone. Blood was sampled for corticosterone before and 5 and 20 min after initiation of stress immobilization. Corticosterone values were compared between wild-type and pendrin-null mice at each of these time points using an unpaired Student's 2-tailed t-test. After 5 min of immobilization stress, corticosterone levels were higher in pendrin-null than in wild-type mice. Wild-type, n = 8; pendrin-null, n = 6. * P < 0.05.
