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. 2015 May 7;138(7):1907–1918. doi: 10.1093/brain/awv107

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© The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Biochemical characterization of sarkosyl-insoluble and soluble tau in Huntington’s disease brains. (A) Western blot analysis of the sarkosyl-insoluble tau fraction, before and after dephosphorylation with alkaline phosphatase (λpp), with the AT8 and a total tau antibody in cortical and striatal Huntington’s disease tissues compared to Alzheimer’s disease (AD) cases and healthy controls (CTL). (B) Western blot analysis of the soluble tau fraction after dephosphorylation with alkaline phosphatase (λpp) with a total tau antibody in cortical (CTX) and striatal (STR) Huntington’s disease tissues, compared to a range of tauopathies (CBD = corticobasal degeneration; PiD = Pick’s disease) and healthy controls. RecTau molecular weight (kDa): 2N4R (45.9), 2N3R (42.6), 1N4R (42.9), 1N3R (39.7), 0N4R (40.0), 0N3R (36.8).