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. 2015 May 7;138(7):1907–1918. doi: 10.1093/brain/awv107

Figure 3.

Figure 3

Mutant huntingtin co-localizes with pathological tau aggregates. (A and B) Mutant HTT aggregates labelled with the EM48 antibody (green) detected within cortical and striatal neurons expressing either 3R-tau or 4R-tau (red). Scale bars in A, A’, B = 25 μm; B’ = 50 μm. (C–F) Confocal microscopy images of mutant HTT aggregates labelled with the EM48 antibody (green) within neurons expressing phosphorylated tau (red) as demonstrated using either the AT8 or pS199 antibodies. The neuronal morphology was further confirmed using the neuronal marker MAP2 (grey). Aggregates stained for both EM48 and AT8 were also found in the extracellular matrix of the cortex and striatum of Huntington’s disease cases as shown in D and E. Scale bars in C–E = 30 μm; F = 20 μm.