Figure 2.

Box plot and receiver operator characteristics analyses comparing the separability of diagnosis-based versus age of onset and BrainAGE-based patient groups. (A) Effects of age of onset (left; early, EO and late, LO) and BrainAGE (right) on diagnostic separability in major depression (MD) versus schizophrenia (SZ) patients. (B) Diagnostic separability of diagnostic groups (major depression versus schizophrenia, left) versus separability in cross-nosological patient groups (right) defined by early versus late disease onset and high versus low BrainAGE (Br+ versus Br−). (C) Receiver operator characteristics analyses of MRI-based decision scores in the classification of diagnosis (left) and EO/Br+ versus LO/Br− groups. SVM = support vector machine; AUC = area under the curve.