Table 2.
Apical Gene-Set and SLC9A3 Complex Association Analysis with CF Lung Disease Severity as Measured by SaKnorm in the Canadian Gene Modifier Study Discovery Sample and in the French Replication Sample
| Location-only Test | Scale-only Test | JLS-Fisher Test | |
|---|---|---|---|
| Apical Gene-Set (3,814 SNPs) | |||
| Canadian Discovery Sample | 0.0876 | 0.0222 | 0.0099 |
| French replication sample | 0.2058 | 0.0077 | 0.0180 |
| SLC9A3 Gene-Based (10 SNPs) | |||
| Canadian Discovery Sample | <0.0001 | 0.0238 | 0.0001 |
| French replication sample | 0.0953 | 0.0415 | 0.0286 |
| Apical Gene-Set Excluding SLC9A3 (3,804 SNPs) | |||
| Canadian Discovery Sample | 0.1319 | 0.0248 | 0.0161 |
| French replication sample | 0.2139 | 0.0076 | 0.0182 |
| SLC9A3 Complex: SLC9A3, SLC9A3R1, SLC9A3R2, and EZR (38 SNPs) | |||
| Canadian Discovery Sample | <0.0001 | 0.0016 | <0.0001 |
| French replication sample | 0.2390 | 0.0245 | 0.0415 |
| Apical Gene-Set Excluding the SLC9A3 Complex (3,776 SNPs) | |||
| Canadian Discovery Sample | 0.178 | 0.0329 | 0.0329 |
| French replication sample | 0.2173 | 0.0099 | 0.0201 |
Individual location-only and scale-only tests and the joint location-scale Fisher (JLS-Fisher) test were performed in the full CGS (n = 1,409) and French (n = 1,232) samples using unrelated individuals (see Material and Methods and Results). p values reported were estimated from 10,000 permutation replicates.