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CFTR CD and DA in the plasma membrane as measured by spatial ICS are strongly cholesterol dependent. CD and DA were normalized to their control values, the CD ratio and the DA ratio, respectively. In the COase condition, cholesterol loss increased the CFTR CD by 30% and decreased the DA by 35% (p < 0.01). Elevating cholesterol in the membrane using CEase reduced the CD by twofold and increased the DA by threefold (p < 0.01). Error bars indicate the mean ± SE.
