Table 3.

Results of univariate and multivariate analysis of factors associated with overall survival

Characteristic		Univariate P value	Multivariate P value	Multivariate Hazard Ratio
Age	≥70	0.856
Sex	male	0.013	0.214	1.54 (95% CI; 0.78–3.30)
Performance status	≥2	0.994
Brinkman index	≥1000	0.019	0.007	2.75 (95% CI; 1.32–5.77)
Neurological dysfunction		0.488
Neurocognitive disorder		0.775
Histology	AC	0.098
Number of brain metastases	≥3	0.115
Prior WBRT		0.098
Pulmonary metastases		<0.001	0.009	3.54 (95% CI; 1.39–8.58)
Liver metastases		0.008	0.619	1.28 (95% CI; 0.45–3.18)
Bone metastases		0.061
Adrenal metastases		0.394
Uncontrolled primary disease		<0.001	0.002	3.04 (95% CI; 1.54–6.03)
LC		0.163
DBF		0.373

AC = adenocarcinoma, WBRT = whole brain radiotherapy, CI = confidence interval, LC = local control, DBF = distant brain failure.