Flow cytometry was used to longitudinally measure T-cell counts in peripheral
blood from no transplant (blue), SHIV-transplant (red), and transplant-SHIV
(green) animals. Arrows indicate time of cART initiation and autologous
transplant, where applicable, for each group. A)
CD4+ T-cell counts/μL over the course of SHIV
infection in each animal. B) Average CD4+ T-cell
counts over 4–6 weeks prior to SHIV challenge. C) Average
CD4+ T- cell counts over 9–10 weeks
post-challenge, prior to Group III animals initiating cART. D)
CD8+ T-cell counts/μL were measured
longitudinally as in A). E) Average CD8+ T-cell
counts over 4–6 weeks prior to SHIV challenge. F) Average
CD8+ T- cell counts over 9–10 weeks
post-challenge, prior to Group III animals initiating cART. Error bars represent
standard deviations between weekly measurements. Statistical significance
between collective measurements from Groups I–II and Group III was
measured by single-tailed Student’s t-test. **
represents p < 0.01, and **** represents p
< 0.0001.