Table 4.
Urinary steroid profilea
| Steroid | Day 0, serum | Day 3, serum | Mean (SD), (n = 16) |
|---|---|---|---|
| Na = 109 mM | Na = 135 mM | ||
| 3β-Hydroxy-5-ene steroids (microgram per 100 ml) | |||
| 16α–Hydroxy DHA | 335 | 32 | 303 (291) |
| 16β–Hydroxy DHA | 11 | 6 | 149 (111) |
| 16-oxoandrostenediol + 15β,16α-Dihydroxy DHA | 330 | 99 | 263 (254) |
| 5-androstene-3β,16α,17β-triol | 116 | 27 | 199 (142) |
| 16α,18-Dihydroxy DHA | 119 | 75 | 426 (341) |
| 16α-Hydroxypregnenolone | 385 | 3 | 427 (380) |
| 5-Androstene-3β,16α,17β,18-tetrol | 48 | 18 | 49 (27) |
| 5-Androstene-3β,15β,16α,17β-tetrol | 97 | 41 | 82 (62) |
| 5-Androstene-3β,15α,16β,17β-tetrol | 53 | 20 | 40 (23) |
| 5-Pregnene-3β,16α,20α,21-tetrol | 18 | 5 | 24 (15) |
| Cortisol metabolites (microgram per 100 ml) | |||
| Tetrahydrocortisone | 166 | 56 | 108 (85) |
| α-Cortolone | 4 | 1 | 32 (53) |
| β-Cortolone | 33 | 6 | 20 (17) |
| 1β-Hydroxytetrohydrocortisone | 4 | 2 | 21 (18) |
| 1β-Hydroxy-β-Cortolone | 38 | 14 | 25 (22) |
| 6α-Hydroxytetrahydrocortisone | 22 | 16 | 86 (78) |
| 6α-Hydroxy-α-cortolone | 27 | 10 | 12 (8) |
| 6α-Hydroxy-β-cortolone | 154 | 67 | 45 (40) |
aall measurements were done at Steroid Profiling Laboratory, Department of Biochemistry, King’s College Hospital, London, UK, which also provided the mean and standard deviations (SD) based on 16 controls for reference