Table 2.
Laboratory values within the 48-h data collection window by definition of severe sepsis
| Laboratory examination | Physician diagnosis | Both criteria | Consensus criteria | p value* | |||
|---|---|---|---|---|---|---|---|
| Percenta | Median (IQR) | Percenta | Median (IQR) | Percenta | Median (IQR) | ||
| WBC, max (103/μl) | 92 % | 10.1 (7.3–16.6) | 97 % | 14.9 (7.5–22.7) | 91 % | 14.6 (8.8–20.8) | <0.001 |
| Platelets, min (103/μl) | 91 % | 148 (70–262) | 96 % | 95 (39–195) | 89 % | 157 (77–287) | <0.001 |
| BUN, max (mg/dl) | 83 % | 13 (8–22) | 93 % | 21 (12–41) | 92 % | 18 (10–31) | <0.001 |
| Creatinine, max (mg/dl) | 92 % | 0.4 (0.3–0.6) | 97 % | 0.5 (0.3–0.9) | 97 % | 0.4 (0.3–0.7) | <0.001 |
| ALT, max (IU/L) | 55 % | 39 (25–67) | 77 % | 53 (28–123) | 62 % | 50 (26–110) | 0.09 |
| Total bilirubin, max (mg/dl) | 53 % | 0.7 (0.4–1.7) | 73 % | 1.0 (0.5–2.9) | 59 % | 0.7 (0.4–3.0) | 0.02 |
| Albumin, min (g/dl) | 66 % | 2.6 (2.2–3.0) | 81 % | 2.5 (2.2–3.0) | 71 % | 2.8 (2.3–3.3) | <0.001 |
| INR, max | 37 % | 1.3 (1.2–1.7) | 64 % | 1.3 (1.2–1.8) | 42 % | 1.3 (1.1–1.8) | 0.80 |
| Lactate, max (mmol/L) | 62 % | 1.4 (1.1–2.0) | 75 % | 2.0 (1.2–3.8) | 62 % | 1.6 (1.1–2.8) | 0.001 |
| ScvO2, min (%) | 28 % | 70 (57–75) | 46 % | 65 (52–74) | 30 % | 65 (49–73) | 0.50 |
| PaO2/FiO2 ratio, min (mmHg) | 47 % | 138 (89–233) | 72 % | 160 (100–236) | 51 % | 144 (87–275) | 0.79 |
| C-reactive peptide, max (mg/dl) | 39 % | 7.1 (2.1–17.8) | 64 % | 9.3 (2.8–20.8) | 43 % | 3.8 (1.6–9.7) | <0.001 |
| Procalcitonin, max (ng/ml) | 12 % | 3.5 (1.1–11.6) | 22 % | 6.4 (1.4–23.0) | 6 % | 1.3 (0.24–5.4) | 0.01 |
max maximum value within the 48-h window around the study day (9:00 am before to 9:00 am after the study day), min minimum value within the 48-h window around the study day (9:00 am before to 9:00 am after the study day), PaO 2 /FiO 2 ratio of partial pressure of oxygen to fraction of inspired oxygen, WBC white blood cell count, BUN blood urea nitrogen, ALT alanine aminotransferase, INR international normalized ratio, ScvO 2 central venous oxygen saturation
*Statistical comparisons using Kruskal-Wallis test
aProportion of each group with available laboratory results