Table 4.
Clinical outcomes by definition of severe sepsis
| Outcome | Physician diagnosis | Both criteria | Consensus criteria | p value* |
|---|---|---|---|---|
| Vasoactive-free days, median (IQR) | 27 (22–28) | 22 (6–26) | 26 (17–28) | <0.001 |
| Ventilator-free days, median (IQR) | 19 (2–27) | 16 (0–24) | 18 (0–26) | 0.07 |
| NPMODSa | 47 (34) | 131 (44) | 97 (36) | 0.10 |
| PICU mortality | 23 (17) | 82 (27) | 57 (21) | 0.042 |
| At least mild disabilityb | 24 (22) | 67 (31) | 50 (24) | 0.15 |
| At least moderate disabilityc | 14 (13) | 36 (17) | 37 (18) | 0.46 |
Data presented as n (%) unless otherwise noted
IQR interquartile range, NPMODS new or progressive multiorgan dysfunction syndrome, PICU pediatric intensive care unit
*Statistical comparisons using Kruskal-Wallis or Fisher’s exact test
aNPMODS considered starting the day after sepsis recognition
bAny increase in Pediatric Overall Performance Category from baseline to hospital discharge in the 534 hospital survivors
cDischarge Pediatric Overall Performance Category ≥3 and an increase of at least 1 from baseline in the 534 hospital survivors