Fig 3. 25OHD serum levels are below the lower limit of normal range levels (30 ng/ml, dotted line) both in healthy subjects and the two cutaneous subsets of SSc.

Nevertheless in healthy subjects the observed 25OHD circulating levels are significantly higher compared to both lcSSc and dcSSc; furthermore, in patients with dcSSc, 25OHD levels are significantly lower compared to the limited cutaneous form. *p<0,01; **p<0,001.