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. 2015 Sep 9;9:5169–5183. doi: 10.2147/DDDT.S81578

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© 2015 Li et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of BN on protein expression of OSX and Col1α1 in MC3T3-E1 cells.

Notes: MC3T3-E1 cells were cultured in differentiation medium and exposed to BN (0.1–10 μM) for 2 weeks. The immunocytochemistry of OSX (A) and immunocytofluorescence of Col1α1 (B) show that BN increased the expression of OSX (C) and Col1α1 (D) in a dose-dependent manner and with a peak at 10 μM. Each sample was measured in triplicate and the experiment was repeated twice with similar results. *P<0.05 versus group without BN; ⁺P<0.05 versus group with 0.1 μM BN; ^#P<0.05 versus group with 1 μM BN. The values shown are the mean ± standard error of the data from independent experiments (C–D).

Abbreviations: BN, baicalein; Col1α1, collagen Iα1; OCN, osteocalcin; OSX, osterix; RUNX2, runt-related transcription factor 2.