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Effects of U50488H on electricity-stimulated contrac-tile response of cathartic colon strips (mean ± SD)
| Concentration (µmol/L) | Basic contraction amplitude before administration (mm) | Contraction amplitude after administration (mm) |
| 0.05 | 11.40 ± 0.21 | 8.98 ± 0.69b |
| 0.10 | 11.40 ± 0.21 | 6.89 ± 0.71ab |
| 1.00 | 11.40 ± 0.21 | 4.43 ± 0.99bd |
P < 0.05 vs 0.05 µmol/L,
P < 0.01 vs before administration,
P < 0.01 vs 0.05 µmol/L.
