Table 3.
Relative content of unsaturated bonds in GM3, GD3 and GD1a gangliosides in intestinal mucosa
| Unsaturated Bonds | Control (BAP) (n = 6) | Control (CRC) (n = 12) | IBD (n = 11) | Pooled SEM | |
| GM3 | 0 | 5.73a | 2.77b | 3.3a,b | 0.41 |
| 1 | 69.96 | 73.40 | 68.34 | 1.30 | |
| 2 | 21.86 | 21.62 | 25.24 | 1.05 | |
| 3 | 2.45 | 2.22 | 3.10 | 0.21 | |
| UI | 1.21 | 1.23 | 1.28 | 0.07 | |
| GD3 | 0 | 9.28 | 6.18 | 5.91 | 1.18 |
| 1 | 59.39c | 58.67c | 87.88d | 2.91 | |
| 2 | 28.28c | 32.98c | 6.21d | 2.45 | |
| 3 | 3.09c | 2.18c | NDd | 0.30 | |
| UI | 1.25c | 1.31c | 1.00d | 0.17 | |
| GD1a | 0 | 5.32a,b | 6.8a | 3.11b | 0.68 |
| 1 | 64.95c | 59.26c | 89.93d | 3.05 | |
| 2 | 26.21c | 30.51c | 8.06d | 2.44 | |
| 3 | 3.55c | 3.43c | NDd | 0.44 | |
| UI | 1.28c | 1.31c | 1.06d | 0.17 |
Major classes of gangliosides stratified by number of unsaturated bonds are reported as average relative percent of respective major ganglioside. Superscript letters (a, b) denote differences (P < 0.05) among study groups; Superscript letters (c, d) denote differences (P < 0.01) among study groups. ND: Not detected; SEM: Standard error of the mean; CRC: Colorectal cancer; BAP: Benign adenomatous polyposis; UI: Unsaturation index; IBD: Inflammatory bowel disease.