Table 1.
Localization of AQP expression in ocular tissues and possible roles in ocular pathologies and/or diseases.
| Ocular component | AQPs expressed | Associated pathology/disease |
|---|---|---|
| Cornea | ||
| Epithelium | AQP3, AQP5 | Fuch’s dystrophy |
| Stroma | AQP1 | Pseudophakic bullous |
| Endothelium | AQP1, AQP4 | Keratopathy Corneal wound repair |
| Lacrimal gland | ||
| Acini | AQP3, AQP4, AQP5 | Sjögren’s syndrome |
| Ducts | AQP4 | |
| Ciliary epithelium | AQP1, AQP4 | |
| Trabecular meshwork | AQP1, AQP4 | |
| Lens | ||
| Epithelium | AQP1, AQP5, AQP7 | Cataract |
| Fiber cells | AQP0, AQP5 | |
| Retina | ||
| Inner limiting membrane | AQP2, AQP7, AQP11 | Diabetic retinopathy |
| Nerve fiber layer | Glaucoma | |
| Ganglion cell layer | AQP0, AQP5, AQP9 | Uveitis |
| Inner plexiform layer | AQP1, AQP4, AQP5 | Retinal detachment |
| Inner nuclear layer | AQP0, AQP1, AQP4, AQP5, AQP9 | Blue light injury Ischemia/reperfusion |
| Outer plexiform layer | AQP1, AQP4, AQP6 | |
| Outer nuclear layer | AQP1, AQP5 | |
| Outer limiting membrane | AQP7 | |
| Photoreceptor layer | ||
| Retinal pigment epithelium | AQP1, AQP2, AQP3, AQP5, AQP7, AQP9 | |