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. 2014 Dec 19;22(7):1081–1093. doi: 10.1038/cdd.2014.212

Figure 6.

Figure 6

Effect of slow-releasing IL4 on peritoneal macrophages from p53+/+ and p53−/− mice. (a–d) Expression of M2 marker genes Arg1 (a), Irf4 (b), Retnla (Fizz1; c) and c-Myc (d) in FACS sorted F4/80+CD11b+ peritoneal macrophages (harvested at day 4) from p53+/+ and p53−/− mice administered (day 0 and day 2) either phosphate-buffered saline (PBS) or IL4C. Data show fold change in gene expression by RT-qPCR (ΔΔCt method) cf. PBS-treated p53+/+ macrophage samples. Individual data for five to six mice per group are presented and are representative of two independent experiments. *P<0.05 cf. IL4C-treated p53+/+ macrophage. (e) Number of viable peritoneal macrophages in p53+/+ and p53−/− mice administered either PBS or IL4C determined at day 4. Results are from five to six mice per group and are representative of two independent experiments. #P<0.05 cf. PBS-treated macrophages; *P<0.05 cf. p53+/+ macrophages