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. 2015 Jan 23;22(7):1192–1202. doi: 10.1038/cdd.2014.217

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Copyright © 2015 Macmillan Publishers Limited

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CD95 stimulation leads to cell cycle progression and Sck-dependent migration. (a) In PANC-1 cells, DNA replication was assessed after 2 h of incorporation with EdU. EdU was labelled with Alexa-488 and detected by Click-iT assay. DNA was stained with Hoechst. Results are expressed as means of three independent experiments±S.D. (*P<0.05). Lower panels show representative histograms of Alexa-488/Hoechst staining. (b) CD95-induced migration is abolished upon Sck KD in PANC-1 cells. Results are expressed as mean of biological duplicates±S.E.M. (*P<0.05). Co, untreated cells; Iso, isotype control; *, specific band. (c) Stimulation of CD95 receptor with CD95L leads to the recruitment of Sck and activation of PI3K/ERK pathways resulting in cell cycle progression