. 2015 May 8;22(7):1071–1080. doi: 10.1038/cdd.2015.50

Table 1. The role of the BCL-2 protein family members in tumour development.

Gene	Role in tumorigenesis	Model	References
Bim (Bcl2l11, Bod)	Tumour suppressor	Eμ-Myc	^{89, 90}
Puma (Bbc3)	Tumour suppressor	Eμ-Myc	⁹¹
Puma (Bbc3)	Required for tumour initiation	Irradiation-induced lymphoma	^{111, 112}
Bax	Tumour suppressor	Eμ-Myc	⁹²
Bmf	Tumour suppressor	Irradiation-induced lymphoma	¹¹⁰
Noxa (Pmaip1)	Tumour suppressor	Irradiation-induced lymphoma	¹¹¹
Bad (Bbc2)	Conflicting reports	Irradiation-induced lymphoma	^{54, 55}
Bcl2	Oncogene	Eμ-Myc	⁸⁶
Bclx (Bcl2l1)	Oncogene; required for lymphoma initiation	Eμ-Myc	^{87, 90, 93, 94}
Mcl1	Oncogene; required for sustained lymphoma growth	Eμ-Myc	^{88, 97}
Mcl1	Oncogene; required for sustained lymphoma growth	p53-deficient thymic lymphoma	¹⁰⁸
Mcl1	Required for sustained lymphoma growth	AML	^{113, 114}