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. 2015 Aug 7;4(10):1122–1130. doi: 10.5966/sctm.2015-0074

Figure 3.

Figure 3.

Postacute CXCL12 gene therapy protects myelin sheath integrity. (A): Immunofluorescent staining of MBP+ myelin sheath in the perifocal region of the ipsilateral hemisphere. (B): Hollow box in schematic brain diagram shows the area of interest, the perifocal striatum in ischemic mice. (C): Immunofluorescent staining of MBP+ myelin sheath in the contralateral hemisphere of an AAV-CXCL12 transferred mouse. (D): IOD quantification of MBP+ signal after MCAO in AAV-GFP, AAV-CXCL12, and AAV-CXCL12/AMD3100 treated groups (n = 3 per group; numbers indicated in each column). Scale bar = 500 μm. Data are presented as mean ± SD. ∗, Statistical significance, p < .05; ∗∗, p < .01. Abbreviations: AMD, adeno-associated virus-C-X-C chemokine ligand 12-AMD3100; CXCL12, adeno-associated virus-C-X-C chemokine ligand 12; GFP, adeno-associated virus-green fluorescent protein; IOD, integral optical density; ipsi/contra, ipsilateral/contralateral; MBP, myelin basic protein; w, week.