Table 2. Comparison of HMSC gene regulation in osteogenic and chondrogenic ECM scaffolds.
Table shows comparison of fold change in gene expression in osteogenic (from our published article [20]) and chondrogenic ECM scaffolds with respect to control scaffolds. Genes that showed a Ct value in the control samples, but did not show any expression in the ECM samples are marked as turned off. A –ve sign denotes down regulation. P-value was calculated using student's t-test.
| GENE | Fold change in OSTEOGENIC scaffold (P-value from t-test) | Fold change in CHONDROGENIC scaffold (P-value from t-test) |
|---|---|---|
| TGFβ1 (Transforming growth factor beta 1) | 7.92 (0.003) | 1.59 (0.036) |
| GDF10 (Growth and differentiation factor 10) | 11.8 (0.016) | Turned off |
| RUNX2 (Runt related transcription factor 2) | 2.35 (0.019) | -1.55 (0.16) |
| BGN (Biglycan) | 3.24 (0.032) | 1.67 (0.017) |
| COLLI (Type I collagen) | 12.06 (0.025) | 1.83 (0.006) |
| FGFR2 (Fibroblast growth factor receptor 2) | 3.89 (0.002) | -2.14 (0.0352) |
| IGF1R (Insulin like growth factor 1 receptor) | 2.02 (0.05) | -12.09 (0.0241) |
| DMP1 (Dentin matrix protein 1) | 3.27 (0.004) | Turned off |
| MMP2 (Matrix metalloproteinase 2) | 5.10 (0.0025) | 1.45 (0.0546) |