Table 4.
Pooled OR (95% CI) for the association between home pesticide exposure and the risk of ALL in the offspring by cytogenetic subtype
| During pregnancy | After birth | |||||||
|---|---|---|---|---|---|---|---|---|
| No of studies | Total N Case/Controls | % exposed | OR1,2, (95% CI) | No of studies | Total N Case/Controls | % exposed | OR1,2, (95% CI) | |
| Any pesticide exposure |
||||||||
| B cell ALL low hyperdiploidy | 33 | 150/3,022 | 64.0/47.1 | 1.77 (1.22,2.56) | 24 | 107/1,387 | 88.8/75.7 | 2.15 (1.26,3.64) |
| B cell ALL high hyperdiploidy | 33 | 361/3,022 | 61.8/47.1 | 1.82 (1.43,2.31) | 24 | 224/1,387 | 81.7/75.7 | 1.32 (0.98,1.79) |
| B cell ALL ETV6-Runx1 t(12;21) | 25 | 219/2,743 | 63.3/49.6 | 1.67 (1.23,2.26) | 16 | |||
| Any MLL arrangement | 25 | 30/2,743 | 70.0/49.6 | 2.12 (0.90,5.00) | 16 | |||
|
Any professional pest control treatment |
||||||||
| B cell ALL low hyperdiploidy | 37 | 183/5,193 | 8.2/5.6 | 1.02 (0.58,1.79) | 37 | 166/5,040 | 22.3/17.1 | 1.13 (0.76,1.67) |
| B cell ALL high hyperdiploidy | 37 | 542/5,193 | 8.7/5.6 | 1.32 (0.95,1.85) | 37 | 530/5,040 | 22.6/17.1 | 1.33 (1.06,1.67) |
| B cell ALL ETV6-Runx1 t(12;21) | 37 | 293/5,193 | 10.9/5.6 | 1.47 (0.98,2.21) | 37 | 287/5,040 | 26.1/17.1 | 1.42 (1.06,1.89) |
| Any MLL arrangement | 37 | 79/5,193 | 6.3/5.6 | 0.95 (0.37,2.44) | 37 | 62/5,040 | 9.7/17.1 | 0.58 (0.26,1.31) |
1
The reference group was those with no exposure in that time period.
2
Adjusted for age, sex, birth year group, study, ethnicity and highest level of education of either parent
3
France (ADELE and ESCALE), NCCLS
4
France (ADELE), NCCLS
5
France (ESCALE), NCCLS
6
Data not shown as only 1 study (NCCLS)
7
Australia, UKCCS, NCCLS