Serial wide-angle NIR-RAFI demonstrates different progression patterns observed along the nasal meridian in representative ABCA4-RD patients (A–D) and summary of all patients (E, F). (A) De novo appearance of outer nasal disease over 4 years in P82. (B) Formation of LDF in the outer nasal region over 5 years in P32. (C, D) Expansion of the LDF in the outer nasal region over 8 and 5 years, in P52 and P72, respectively. All eyes are shown as equivalent right eyes and individually contrast stretched. (E, F) Eccentricity of the LDF in the inner and outer nasal retina in all patients as a function of age. Symbols connected by lines represent serial follow-up in the same eye.