Table 4.

Brain MRI abnormal T2 signal intensity.

4-Month pilot study			12-Month extension study
Subject number	Baseline	End of Study	Baseline	Six months	End of study
1	2	2	2	N/A	N/A
2	N/A	N/A	0	0	N/A
3	0	0	N/A	N/A	N/A
4	2	N/A	N/A	N/A	N/A
5	1	1	1	2	2

Grading system: score signal changes on T2-weighted images as 0, absent; 1, patchy and confined to the periventricular area; 2, patchy but in other white matter areas as well as periventricular; and 3, diffuse.