Table 5.

Brain MRI enlargement of perivascular spaces.

4-Month pilot study			12-Month extension study
Subject number	Baseline	End of study	Baseline	Six months	End of study
1	2	2	3	N/A	N/A
2	N/A	N/A	1	1	N/A
3	0	0	N/A	N/A	N/A
4	2	N/A	N/A	N/A	N/A
5	3	2	3	2	2

Grading system: 0, no enlargement; 1, <3 mm enlargement; 2, between 3 and 8 mm enlargement; and 3, >8 mm enlargement.