Figure 4.

Transcriptional cascade showing Klf4 and Klf5 expression during adipogenesis. The adipogenic program involves a transcriptional cascade with early participation of KLF4 and KLF5, which depends on GSK3β activity. Forced expression of Klf4 showed that Cebpb expression was not dependent on KLF4. All-trans retinoic acid impairs the adipogenic program after Cebpb expression and up-stream of Klf4 and Klf5 expression. Solid line means direct relationship and dashed line means an indirect or multistep involved relationship. This schematic was constructed from cited references 1 and 3.