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Bile acid signaling in mice fed a high-fat diet ad libitum or time-restricted feeding. The composition of the total bile acid pool is determined by the action of the liver (synthesis), the gut (reabsorption and excretion) and the gut microbiota (bile acids modification). Bile acids feedback on the liver and the gut regulate bile acids homeostasis and also influence their metabolic functions. They also act on the adipose tissue to regulate fat storage and utilization.
