Table 3.

Published series on the natural history of renal masses.

	Year	Patients/lesions (n)	Mean age (years)	Mean initial MTD (cm)	Mean follow-up (months)	Mean LGR (cm/year)	Mean VGR (cm3/year)	Progression to metastasis, n (%)	Pathologic RCC
Fujimoto et al. [10]	1995	6/6	59.7	2.47	24	0.47	9.7	0 (0)	5/5
Bosniak et al. [11]	1995	37/40	65.5	1.73	39	0.36	5.26	0 (0)	22/26
Oda et al. [12]	2003	16/16	54a	2.0a	25	0.54a	—	0 (0)	16/16*
Volpe et al. [7]	2004	29/32	71a	2.48	27.9	0.1	3.8	0 (0)	8/9
Wehle et al. [13]	2004	29/29	70	1.83	32	0.12	—	0 (0)	3/4
Kato et al. [5]	2004	18/18	56.5	2.0	27	0.42	4.4	0 (0)	18/18*
Lamb et al. [14]	2004	36/36	76.1	7.2	27.7	0.39	—	1 (2.8)	23/24
Chawla et al. [15]	2006	49/61	71	2.97	36	0.2	—	1 (1.6)	16/21
Youssif et al. [16]	2007	35/44	71.8	2.2	47.6	0.21	2.7	2 (5.7)	6/8
Kouba et al. [17]	2007	43/46	67	2.92	32.8	0.7	—	0 (0)	12/14
Siu et al. [18]	2007	41/47	68	2.0	29	0.27	—	1 (2.4)	10/16
Fernando et al. [19]	2007	13/13	80.4	5.01	38.38	0.17	11.97	1 (7.7)	0
Matsuzaki et al. [20]	2007	15/15	67	2.2	38	0.06	0.67	0 (0)	3/3
Lee et al. [8]	2008	30/30	65.5	2.6	12.6	0.59	19.1	3 (10.0)	30/30*
Beisland et al. [21]	2009	63/65	76.3	4.3	33	0.66	—	2 (3.2)	15/18
Crispen et al. [22]	2009	154/173	69	2.45	31	0.285	17.0	2 (1.3)	52/61
Rosales et al. [23]	2010	212/223	71a	2.8a	35a	0.34a	—	4 (1.9)	32/40
Hwang et al. [24]	2010	56/58	64.3	2.1	22	0.21	1.9	0 (0)	10/15
Jewett et al. [25]	2011	127/151	73	2.1	28	0.13	—	1 (0.7)	37/46
Li et al. [4]	2012	32/32	52.2	2.14	46	0.8	—	0 (0)	32/32*
Mehrazin et al. [26]	2014	68/72	68.9	5.3	38.9	0.44	—	0 (0)	16/23
Brunocilla et al. [27]	2014	62/64	75	2.0	91.5	0.4	4.6	1 (1.6)	14/16
Total		1171/1271	69.5	2.82	34.6	0.33	9.48	19 (1.6)	380/444
This study		60/61	55	2.32	39.46	0.86	20.96	1 (1.6)	61/61

^aMedian.

—: not stated

^∗All cases received delayed surgical intervention and were confirmed to be renal cell carcinoma (RCC) pathologically.