Table 4.
Increments in ANCa following Granulocyte Transfusions in NIH Case Series
| Patient | No. of Granulocyte Transfusions (No. with Same Day Posttransfusion ANC) |
Mean Time from Pre-ANCb to Transfusion (hr) | Mean Time Transfusion to Post-ANCc (hr) | Mean Overall ANC Increment (×109/L) |
Mean Same-dayd ANC Increment (×109/L) |
|---|---|---|---|---|---|
| 1 | 7 (3) | 13:38 | 2:06 | 1.86 | 1.92 |
| 2 | 20 (7) | NAe | NA | 0.44 | 0.93 |
| 3 | 7 (4) | 15:54 | 1:59 | 0.13 | 0.42 |
| 4 | 11 (2) | 13:02 | 2:54 | 0.97 | 2.52 |
| 5 | 2 (1) | 17:14 | 1:55 | 6.67 | 10.27 |
| 6 | 8 (2) | 6:24 | 1:55 | 3.1 | 3.21 |
| 7 | 6 (1) | 10:31 | 5:05 | 2.85 | 0.84 |
| 8 | 5 (1) | 15:21 | 0:25 | 0.03 | 0.82 |
| 9 | 6 (2) | 6:14 | 7:12 | 8.78 | 10.88 |
| 10f | 39 (2) | 6:35 | 6:44 | 1.09 | 1.67 |
| 11f | 12 (0) | NA | NA | 1.17 | NA |
| Series Mean | 13:39 | 3:32 | 2.46 | 3.35 |
a
ANC= Absolute neutrophil count
b
Pre-ANC = ANC sample drawn prior to starting granulocyte transfusion.
c
Post-ANC = ANC sample drawn following granulocyte transfusion.
d
Same-day ANC represents those cases in which pre- and posttransfusion counts were obtained on the same calendar day (before midnight).
e
NA = not available.
f
HLA-alloimmunization occurred during the course of transfusions in Patients #10 and 11, and was associated with a decrease in ANC increments (see text).