Table 1.
Differences in Homozygosity Measures between Individuals with Coronary Artery Disease and Control Subjects: Combined Analysis
| Measure |
Un-adjusted Analysis |
Age-Adjusted Analysis |
Age- and Sex-Adjusted Analysis |
||||||
|---|---|---|---|---|---|---|---|---|---|
| β-coefficient/OR | 95% CI | p Value | β-coefficient/OR | 95% CI | p Value | β-coefficient/OR | 95% CI | p Value | |
| Average ROH number | 0.39 | 0.20, 0.57 | 3.92 × 10−5 | 0.67 | 0.47, 0.86 | 4.12 × 10−11 | 0.63 | 0.42, 0.83 | 1.49 × 10−9 |
| Average ROH length (kb) | 2.51 | −0.80, 5.82 | 0.14 | 5.19 | 1.64, 8.75 | 0.004 | 4.50 | 0.85, 8.15 | 0.016 |
| Average total length of ROHs (kb) | 688.11 | 314.44, 1,061.78 | 3.08 × 10−4 | 1,145.15 | 743.95, 1,546.35 | 2.24 × 10−8 | 1,046.92 | 634.37, 1,459.48 | 6.61 × 10−7 |
| FROH | 1.07 | 1.03, 1.10 | 8.63 × 10−5 | 1.14 | 1.10, 1.18 | 2.21 × 10−13 | 1.13 | 1.09, 1.17 | 1.57 × 10−11 |
Data for number, average length, and total length of homozygosity runs (ROHs) are β-coefficients (with respective confidence intervals and level of statistical significance [p value] from regressing homozygosity measures on case-control status with adjustment for cohort, age, and sex, where appropriate); data on FROH (proportion of autosomal genome in ROHs) are expressed as odds ratios (OR) of coronary artery disease risk (with confidence intervals and level of statistical significance) with adjustment for cohort, age, and sex (where appropriate). 95% CI indicates 95% confidence intervals.