Table 2.

Frequency of Overlapping Consensus ROHs with a Potentially Increasing or Decreasing Risk of Coronary Artery Disease: Analysis Stratified on Number of SNPs in Overlapping Consensus ROHs

	Overlapping Consensus ROHs	Expected	Observed	p Value
Overall	↑ CAD risk	50% (8,494.5)	54.6% (9,278)	2.69 × 10−33
↓ CAD risk	50% (8,494.5)	45.4% (7,711)
Group 0	↑ CAD risk	50% (926)	55.1% (1,020)	1.37 × 10−5
2–9 SNPs	↓ CAD risk	50% (926)	44.9% (832)
Group 1	↑ CAD risk	50% (3,009)	53.4% (3,214)	1.33 × 10−7
10–49 SNPs	↓ CAD risk	50% (3,009)	46.6% (2,804)
Group 2	↑ CAD risk	50% (1,704)	55.0% (1,876)	4.09 × 10−9
50–99 SNPs	↓ CAD risk	50% (1,704)	45.0% (1,532)
Group 3	↑ CAD risk	50% (2,855.5)	55.5% (3,168)	1.39 × 10−16
100+ SNPs	↓ CAD risk	50% (2,855.5)	44.6% (2,543)

Data are counts and percentages. Overlapping consensus ROHs were classified as increasing (↑) and decreasing (↓) risk of coronary artery disease (CAD) based on the magnitude of their odds ratio (OR) for CAD; OR > 1.0 indicates increasing risk of CAD and OR < 1.0 indicates decreasing risk of CAD. p value indicates level of statistical significance from binomial test, and the size (and thus the number of SNPs) in each overlapping consensus ROH depends on the length of the consensus sequence common for the studies: from 2 to 100+ SNPs were identified in these regions.