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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Int J Hyperthermia. 2015 May 19;31(6):693–701. doi: 10.3109/02656736.2015.1037800

Figure 1.

Figure 1

Interstitial fluid pressure decreases and perfusion measured by LDF increases following systemic heating (n = 5). (A) Plot of IFP measured in FaDu tumours 2 h and 24 h after systemic heating to 39.5 °C for 4 h. A significant reduction in IFP was observed in the tumours in heated mice as compared to those in unheated control animals (ANOVA p <0.01**). (B) Plot of LDF measurements on FaDu in blood perfusion units (BPU) in tumours showing significant increase in relative tumour perfusion in heated mice at 2 h and 24 h post-heating in comparison to those in unheated animals (ANOVA p <0.001***). (C) Plot of tumour interstitial fluid pressures (IFP) in xenografts of a resected patient head and neck tumour (no. 19705) grown subcutaneously in SCID mice at 2 h and 24 h after systemic heating to 39.5 °C for 4 h. IFPs in tumours post-heating show significant decrease (ANOVA p <0.01**). (D) Plot of relative tumour perfusion measurements using LDF on mice bearing the same patient tumour xenografts show small increases in relative tumour perfusion in heated mice at both 2 h and 24 h post-heating. The increases were not statistically significant.