Figure 3.

The Underlying Functional Architecture of a Trait Affects Fine-Mapping Performance

We simulated two classes of disease architectures: A1 (solid line) and A2 (dashed line). Architecture A1 was based on the functional enrichment observed in Gusev et al.³⁵ and had a strong enrichment within a single DHS class. Architecture A2 was simulated with a more diffuse enrichment in various cell types and classes and was based on what we empirically observed in the RA dataset. Displayed on top of each point is the percentage of SNPs falling within that annotation and its corresponding enrichment.