Table 4.
Integrating Trans-ethnic Association Strength with Functional Data Promotes a Number of SNPs to Attain a High Posterior Probability for Causality
| rsID | Chromosomal Position | European Association (Z Score) | Asian Association (Z Score) | Posterior Probability without Annotations | Posterior Probability with Annotations | Functional Annotations |
|---|---|---|---|---|---|---|
| rs2476601 | chr1: 114,377,568 | −26.04 | NA | 1.00 | 1.00 | coding exons, skin keratinocyte DHSs |
| rs7731626 | chr5: 55,444,683 | −9.84 | NA | 1.00 | 1.00 | GM12865 DHSs, Th2 DHSs, immune enhancers |
| NA | chr1: 2,523,878 | −5.22 | −4.18 | 1.00 | 1.00 | immune enhancers |
| rs1893592 | chr21: 43,855,067 | −5.73 | −4.01 | 1.00 | 1.00 | coding exons, immune enhancers |
| NA | chr19: 10,771,941 | −6.13 | NA | 1.00 | 1.00 | immune enhancers |
| rs72767222 | chr5: 55,440,788 | 5.11 | NA | 0.99 | 0.99 | skin keratinocyte DHSs, immune enhancers |
| rs12715125 | chr3: 27,763,427 | 5.58 | NA | 0.95 | 0.99 | coding exons, GM12865 DHSs, Th2 DHSs, skin keratinocyte DHSs, immune enhancers |
| rs71508903 | chr10: 63,779,871 | 7.26 | 5.88 | 0.76 | 0.93 | GM12865 DHSs, skin keratinocyte DHSs, immune enhancers |
| rs12693993 | chr2: 204,595,597 | −2.74 | −1.76 | 0.68 | 0.88 | Th2 DHSs, skin keratinocyte DHS, immune enhancers |
| rs968567 | chr11: 61,595,564 | −4.95 | NA | 0.29 | 0.85 | coding exons, GM12865 DHSs, Th2 DHSs, skin keratinocyte DHSs, immune enhancers |
| rs909685 | chr22: 39,747,671 | 6.29 | 4.62 | 0.65 | 0.84 | Th2 DHSs, skin keratinocyte DHSs, immune enhancers |
| rs657075 | chr5: 131,430,118 | 2.54 | 4.46 | 0.73 | 0.82 | skin keratinocyte DHSs, immune enhancers |
We applied our framework across all 89 GWAS RA loci with relevant functional data. Displayed in this table are SNPs achieving a trans-ethnic posterior probability of greater than 0.8. Abbreviations are as follows: NA, not applicable; Th2, T helper 2 cell.